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The compounds of the invention may be administered orally in the form of
tablets, capsules, suspensions, solutions or other means suitable for such
ingestion, perhaps as an admixture with other compounds to enhance absorption
into the blood stream or to otherwise assist in achieving the desired effects.
The compounds of the invention may also be administered parenterally, as a
subcutaneous, intramuscular or intravenous injection, or by way of an implant
for sustained release. When administered parenterally, the compounds of' the
invention are to be dissolved in physiologically acceptable liquid media and/or
otherwise compounded in accordance with the known pharmaceutical art. Another
mode of administering the compounds of the invention may be a transdermal patch,
in which entry of the compounds of the invention into the body is facilitated
via acceptable carrier molecules.
Unless otherwise defined, the technical and scientific terminology used herein
has the same meaning as understood by those informed of the art to which this
invention belongs.
Examples
Described herein are preferred or representative materials and methods for the
practice of the invention. The materials and methods, along with the examples,
are only illustrative in the sense that these are not intended to be limiting.
Example 1
The Similar Physiological Effects of the Compounds of the Invention
Representative compounds of Formulas1, 1I, and111 are shown in FIG. 2. That
compounds of Formulas1, II and 111 have like physiological properties, and as
such can be considered as similar or equivalent for therapeutic purposes, was
tested via a rodent model.
Female montane voles, Microtis montanus, received intraperitoneal
injections of representative compounds belonging to Formulas1, II and MI, and
shown in FIG. 2, for three consecutive days and sacrificed 24 hours after the
last injection to examine uterine weight response. To assess the properties of
each representative compound, pure ones made by chemical means (University of
Utah Department of Chemistry, Salt Lake City, UT) were prepared specifically for
this test. All compounds were injected at a dose level of 5ug/day, dissolved in
5% propylene glycol for a total injection volume of 0. 5ml. Control animals
received 0. 5ml of 5% propylene glycol only. All voles were 4-5 weeks old and
weighed 25-29 g.
All compounds belonging to FormulasI, II and III caused a statistically
significant increase in uterine weights (FIG. 3). On average, the uterine weight
in voles receiving these was 22. 8 g, 50% greater than for the control group.
The greatest average weight increase, 82% more than the uterine weight for the
control voles, was in those females administered6-methoxy-2-benzoxazolinone, but
even the least effect of a compound belonging to
Formulas1, 11 or 111, that for5-methoxy-2-benzoxazolinone, entailed a 32%
increase in uterine weight. The results show that physiological effects or modes
of action are held in common by the compounds of the invention.
Example 2
Compounds of the Invention as an Antidepressant and Aphrodisiac in Human Males
This component of the invention relates to a method
for lessening depression and otherwise bettering mood or feelings of well-being,
said method comprising the administration to human males of an effective amount
of one or more of the compounds of the invention, defined above and in FIG. 1.
This component of the invention also relates to a method for treating sexual
dysfunction or otherwise increasing sexual desire and performance, including but
not necessarily limited to lacking interest in sex, problems with arousal, not
enjoying sex, and anxiety about sexual performance, said method comprising the
administration of an effective amount of one or more of the active compounds of
the invention.
A double-blind crossover study was done on human males to test compounds of the
invention as a therapeutic agent for treating depression or otherwise elevating
mood as well as bettering sexual function. The trial had three phases, each two
weeks in duration, during which participants took compounds of the invention for
one phase or two weeks. The daily dose was made up from compounds of the
invention naturally contained in the ground leaves from immature corn plants,
30-45 cm tall, standardized with synthesized 6-methoxy-benzoxazolinone, to a
total of15-mg 6-methoxy-2-benzoxazolinone. A dose of15-mg was selected because
this was considered a likely minimum effective daily amount for humans,
extrapolated from prior studies on rodents, rabbits and other animals. Previous
anecdotal trials on humans done by the inventors suggested that a 15-mg daily
dose had a desirable effect, but no adverse consequences to health.
Weekly assessments of depression or mental well being and sexual function were
done via widely accepted indices : to quantify depression and generalized
anxiety disorders, the Hospital Anxiety and Depression Scale (HAD) ; and for
sexual desire, psychological arousal, and overall sexual outlook, the Arizona
Sexual Experience Index (ASEX).
Phase One lasted 14 days, during which participants took daily doses of the
invention or a placebo. Assignation of the invention or placebo to male
participants was done randomly. Immediately prior to the 14 days comprising
Phase One, an initial physical examination and blood analysis were done. At that
time, each male filled out HAD and ASEX forms to assess mental well being and
sexual function, was checked for sitting and standing blood pressure and pulse,
and gave the blood sample needed for the biochemical analyses.
Phase Two consisted of a seven-day period immediately after Phase One, during
which neither invention nor placebo was taken. During Phase Two, physical
examination and laboratory analyses were again done. In Phase Three which lasted
14 days, participants again took either invention or a placebo. Assignation of
the invention or placebo was done according to the sort of capsule taken during
Phase One. If a participant took a compound of the invention in Phase One, then
placebo was administered during Phase Three, and vice versa. Immediately after
finishing Phase Three, a physical examination and laboratory analyses were again
done. After completing Phase Three, each participant was asked prepared
questions as well as solicited for any comments and impressions concerning
invention use.
The results are tabulated in FIG. 4, and these indicate that the compounds of
the invention have significant positive effect on depression or mood. Fourteen
of the 15 participants properly completed the study and only data for these
individuals were used for analysis. HAD scores exceeding 20. 0 denote clinical
depression, but lower ones can also be associated with dispirited mood. Only two
males entered the trial with HAD values exceeding the clinical minimum (21. 0
and 23. 0). Still, 12 of 14 subjects showed bettered mood, improved feelings of
well being or lessened depression after taking compounds of the invention.
Decreases in HAD scores over the two-week time span were as much as 15 and
averaged 5. 2. The two clinically depressed subjects showed decreases in HAD
values of 5. 0 and 15. 0. The average HAD score went from 13. 5 at the onset of
the study to 9. 1 after two weeks of taking compounds of the invention, very
significant statistically. Participants showed no statistically detectable
changes while taking placebo.
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White Eagle Soaring: Dream Dancer of the 7th Fire
This is a crazy world. What can be
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hinges first on the nation's banks and money system. That's why we
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A New Beginning: A Practical Course in Miracles.
You CAN
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Disclaimer: The
statements on www.real-dream-catchers.com have not been evaluated by the FDA.
These dream catchers are not intended to diagnose nor treat nor cure any
disease or illnes
© 2007, Allen
Aslan Heart / White Eagle Soaring of the Little Shell Pembina Band,
aTreaty
Tribe of the Ojibwe Nation.
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